The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals.
Identifieur interne : 000196 ( Main/Exploration ); précédent : 000195; suivant : 000197The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals.
Auteurs : Daniel Ferreira [Suède] ; Oskar Hansson [Suède] ; José Barroso [Espagne] ; Yaiza Molina [Espagne] ; Alejandra Machado [Espagne] ; Juan Andrés Hernández-Cabrera [Espagne] ; J-Sebastian Muehlboeck [Suède] ; Erik Stomrud [Suède] ; Katarina N Gga [Suède] ; Olof Lindberg [Suède] ; David Ames [Australie] ; Grégoria Kalpouzos [Suède] ; Laura Fratiglioni [Suède] ; Lars B Ckman [Suède] ; Caroline Graff [Suède] ; Patrizia Mecocci [Italie] ; Bruno Vellas [France] ; Magda Tsolaki [Grèce] ; Iwona Kłoszewska [Pologne] ; Hilkka Soininen [Finlande] ; Simon Lovestone [Royaume-Uni] ; H Kan Ahlström [Suède] ; Lars Lind [Suède] ; Elna-Marie Larsson [Suède] ; Lars-Olof Wahlund [Suède] ; Andrew Simmons [Suède] ; Eric Westman [Suède]Source :
- Hippocampus [ 1098-1063 ] ; 2017.
Abstract
Alzheimer's disease is characterized by hippocampal atrophy. Other factors also influence the hippocampal volume, but their interactive effect has not been investigated before in cognitively healthy individuals. The aim of this study is to evaluate the interactive effect of key demographic and clinical factors on hippocampal volume, in contrast to previous studies frequently investigating these factors in a separate manner. Also, to investigate how comparable the control groups from ADNI, AIBL, and AddNeuroMed are with five population-based cohorts. In this study, 1958 participants were included (100 AddNeuroMed, 226 ADNI, 155 AIBL, 59 BRC, 295 GENIC, 279 BioFiNDER, 398 PIVUS, and 446 SNAC-K). ANOVA and random forest were used for testing between-cohort differences in demographic-clinical variables. Multiple regression was used to study the influence of demographic-clinical variables on hippocampal volume. ANCOVA was used to analyze whether between-cohort differences in demographic-clinical variables explained between-cohort differences in hippocampal volume. Age and global brain atrophy were the most important variables in explaining variability in hippocampal volume. These variables were not only important themselves but also in interaction with gender, education, MMSE, and total intracranial volume. AddNeuroMed, ADNI, and AIBL differed from the population-based cohorts in several demographic-clinical variables that had a significant effect on hippocampal volume. Variability in hippocampal volume in individuals with normal cognition is high. Differences that previously tended to be related to disease mechanisms could also be partly explained by demographic and clinical factors independent from the disease. Furthermore, cognitively normal individuals especially from ADNI and AIBL are not representative of the general population. These findings may have important implications for future research and clinical trials, translating imaging biomarkers to the general population, and validating current diagnostic criteria for Alzheimer's disease and predementia stages.
DOI: 10.1002/hipo.22721
PubMed: 28394034
Affiliations:
- Australie, Espagne, Finlande, France, Grèce, Italie, Pologne, Royaume-Uni, Suède
- Angleterre, East Middle Sweden, Oxfordshire, Svealand
- Oxford, Stockholm, Uppsala
- Université d'Oxford, Université d'Uppsala
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Neurogeriatrics, Department of Neurobiology Care Sciences and Society, Centre for Alzheimer Research, Karolinska Institutet, Stockholm, 14157, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Neurogeriatrics, Department of Neurobiology Care Sciences and Society, Centre for Alzheimer Research, Karolinska Institutet, Stockholm, 14157</wicri:regionArea><wicri:noRegion>14157</wicri:noRegion></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Gerontology and Geriatrics, University of Perugia, Perugia, 06100, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Gerontology and Geriatrics, University of Perugia, Perugia, 06100</wicri:regionArea><wicri:noRegion>06100</wicri:noRegion></affiliation></author><author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U 558, University of Toulouse, Toulouse, 31024, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 558, University of Toulouse, Toulouse, 31024</wicri:regionArea><wicri:noRegion>31024</wicri:noRegion><wicri:noRegion>31024</wicri:noRegion></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:affiliation>3rd Department of Neurology, Aristoteleion Panepistimeion Thessalonikis, Thessaloniki, 54124, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>3rd Department of Neurology, Aristoteleion Panepistimeion Thessalonikis, Thessaloniki, 54124</wicri:regionArea><wicri:noRegion>54124</wicri:noRegion></affiliation></author><author><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kłoszewska">Iwona Kłoszewska</name><affiliation wicri:level="1"><nlm:affiliation>Medical University of Lodz, Lodz, 92216, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Medical University of Lodz, Lodz, 92216</wicri:regionArea><wicri:noRegion>92216</wicri:noRegion></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:affiliation>University of Eastern Finland and Kuopio University Hospital, Kuopio, 70211, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Eastern Finland and Kuopio University Hospital, Kuopio, 70211</wicri:regionArea><wicri:noRegion>70211</wicri:noRegion></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Warneford Hospital University of Oxford, Oxford, OX37JX, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, Warneford Hospital University of Oxford, Oxford, OX37JX</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Ahlstrom, H Kan" sort="Ahlstrom, H Kan" uniqKey="Ahlstrom H" first="H Kan" last="Ahlström">H Kan Ahlström</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, 75185, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, 75185</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, 75185, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala, 75185</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Larsson, Elna Marie" sort="Larsson, Elna Marie" uniqKey="Larsson E" first="Elna-Marie" last="Larsson">Elna-Marie Larsson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, 75185, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, 75185</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Wahlund, Lars Olof" sort="Wahlund, Lars Olof" uniqKey="Wahlund L" first="Lars-Olof" last="Wahlund">Lars-Olof Wahlund</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157</wicri:regionArea><wicri:noRegion>14157</wicri:noRegion></affiliation></author><author><name sortKey="Simmons, Andrew" sort="Simmons, Andrew" uniqKey="Simmons A" first="Andrew" last="Simmons">Andrew Simmons</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157</wicri:regionArea><wicri:noRegion>14157</wicri:noRegion></affiliation></author><author><name sortKey="Westman, Eric" sort="Westman, Eric" uniqKey="Westman E" first="Eric" last="Westman">Eric Westman</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157</wicri:regionArea><wicri:noRegion>14157</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28394034</idno><idno type="pmid">28394034</idno><idno type="doi">10.1002/hipo.22721</idno><idno type="wicri:Area/PubMed/Corpus">000A57</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A57</idno><idno 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Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157</wicri:regionArea><wicri:noRegion>14157</wicri:noRegion></affiliation></author><author><name sortKey="Hansson, Oskar" sort="Hansson, Oskar" uniqKey="Hansson O" first="Oskar" last="Hansson">Oskar Hansson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Malmö, 20502, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Malmö, 20502</wicri:regionArea><wicri:noRegion>20502</wicri:noRegion></affiliation></author><author><name sortKey="Barroso, Jose" sort="Barroso, Jose" uniqKey="Barroso J" first="José" last="Barroso">José Barroso</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Psychology, Psychobiology and Methodology, University of La Laguna, La Laguna, 38071, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Clinical Psychology, Psychobiology and Methodology, University of La Laguna, La Laguna, 38071</wicri:regionArea><wicri:noRegion>38071</wicri:noRegion></affiliation></author><author><name sortKey="Molina, Yaiza" sort="Molina, Yaiza" uniqKey="Molina Y" first="Yaiza" last="Molina">Yaiza Molina</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Psychology, Psychobiology and Methodology, University of La Laguna, La Laguna, 38071, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Clinical Psychology, Psychobiology and Methodology, University of La Laguna, La Laguna, 38071</wicri:regionArea><wicri:noRegion>38071</wicri:noRegion></affiliation></author><author><name sortKey="Machado, Alejandra" sort="Machado, Alejandra" uniqKey="Machado A" first="Alejandra" last="Machado">Alejandra Machado</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Psychology, Psychobiology and Methodology, University of La Laguna, La Laguna, 38071, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Clinical Psychology, Psychobiology and Methodology, University of La Laguna, La Laguna, 38071</wicri:regionArea><wicri:noRegion>38071</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez Cabrera, Juan Andres" sort="Hernandez Cabrera, Juan Andres" uniqKey="Hernandez Cabrera J" first="Juan Andrés" last="Hernández-Cabrera">Juan Andrés Hernández-Cabrera</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Psychology, Psychobiology and Methodology, University of La Laguna, La Laguna, 38071, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Clinical Psychology, Psychobiology and Methodology, University of La Laguna, La Laguna, 38071</wicri:regionArea><wicri:noRegion>38071</wicri:noRegion></affiliation></author><author><name sortKey="Muehlboeck, J Sebastian" sort="Muehlboeck, J Sebastian" uniqKey="Muehlboeck J" first="J-Sebastian" last="Muehlboeck">J-Sebastian Muehlboeck</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157</wicri:regionArea><wicri:noRegion>14157</wicri:noRegion></affiliation></author><author><name sortKey="Stomrud, Erik" sort="Stomrud, Erik" uniqKey="Stomrud E" first="Erik" last="Stomrud">Erik Stomrud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Malmö, 20502, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Malmö, 20502</wicri:regionArea><wicri:noRegion>20502</wicri:noRegion></affiliation></author><author><name sortKey="N Gga, Katarina" sort="N Gga, Katarina" uniqKey="N Gga K" first="Katarina" last="N Gga">Katarina N Gga</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Malmö, 20502, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Malmö, 20502</wicri:regionArea><wicri:noRegion>20502</wicri:noRegion></affiliation></author><author><name sortKey="Lindberg, Olof" sort="Lindberg, Olof" uniqKey="Lindberg O" first="Olof" last="Lindberg">Olof Lindberg</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157</wicri:regionArea><wicri:noRegion>14157</wicri:noRegion></affiliation></author><author><name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name><affiliation wicri:level="1"><nlm:affiliation>National Ageing Research Institute, Parkville, Victoria, 3050, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>National Ageing Research Institute, Parkville, Victoria, 3050</wicri:regionArea><wicri:noRegion>3050</wicri:noRegion></affiliation></author><author><name sortKey="Kalpouzos, Gregoria" sort="Kalpouzos, Gregoria" uniqKey="Kalpouzos G" first="Grégoria" last="Kalpouzos">Grégoria Kalpouzos</name><affiliation wicri:level="3"><nlm:affiliation>Aging Research Center (ARC), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, 113 30, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Aging Research Center (ARC), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, 113 30, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Fratiglioni, Laura" sort="Fratiglioni, Laura" uniqKey="Fratiglioni L" first="Laura" last="Fratiglioni">Laura Fratiglioni</name><affiliation wicri:level="3"><nlm:affiliation>Aging Research Center (ARC), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, 113 30, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Aging Research Center (ARC), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, 113 30, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="B Ckman, Lars" sort="B Ckman, Lars" uniqKey="B Ckman L" first="Lars" last="B Ckman">Lars B Ckman</name><affiliation wicri:level="3"><nlm:affiliation>Aging Research Center (ARC), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, 113 30, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Aging Research Center (ARC), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, 113 30, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurogeriatrics, Department of Neurobiology Care Sciences and Society, Centre for Alzheimer Research, Karolinska Institutet, Stockholm, 14157, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Neurogeriatrics, Department of Neurobiology Care Sciences and Society, Centre for Alzheimer Research, Karolinska Institutet, Stockholm, 14157</wicri:regionArea><wicri:noRegion>14157</wicri:noRegion></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Gerontology and Geriatrics, University of Perugia, Perugia, 06100, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Gerontology and Geriatrics, University of Perugia, Perugia, 06100</wicri:regionArea><wicri:noRegion>06100</wicri:noRegion></affiliation></author><author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U 558, University of Toulouse, Toulouse, 31024, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 558, University of Toulouse, Toulouse, 31024</wicri:regionArea><wicri:noRegion>31024</wicri:noRegion><wicri:noRegion>31024</wicri:noRegion></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:affiliation>3rd Department of Neurology, Aristoteleion Panepistimeion Thessalonikis, Thessaloniki, 54124, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>3rd Department of Neurology, Aristoteleion Panepistimeion Thessalonikis, Thessaloniki, 54124</wicri:regionArea><wicri:noRegion>54124</wicri:noRegion></affiliation></author><author><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kłoszewska">Iwona Kłoszewska</name><affiliation wicri:level="1"><nlm:affiliation>Medical University of Lodz, Lodz, 92216, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Medical University of Lodz, Lodz, 92216</wicri:regionArea><wicri:noRegion>92216</wicri:noRegion></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:affiliation>University of Eastern Finland and Kuopio University Hospital, Kuopio, 70211, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Eastern Finland and Kuopio University Hospital, Kuopio, 70211</wicri:regionArea><wicri:noRegion>70211</wicri:noRegion></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Warneford Hospital University of Oxford, Oxford, OX37JX, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, Warneford Hospital University of Oxford, Oxford, OX37JX</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Ahlstrom, H Kan" sort="Ahlstrom, H Kan" uniqKey="Ahlstrom H" first="H Kan" last="Ahlström">H Kan Ahlström</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, 75185, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, 75185</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, 75185, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala, 75185</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Larsson, Elna Marie" sort="Larsson, Elna Marie" uniqKey="Larsson E" first="Elna-Marie" last="Larsson">Elna-Marie Larsson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, 75185, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, 75185</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Wahlund, Lars Olof" sort="Wahlund, Lars Olof" uniqKey="Wahlund L" first="Lars-Olof" last="Wahlund">Lars-Olof Wahlund</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157</wicri:regionArea><wicri:noRegion>14157</wicri:noRegion></affiliation></author><author><name sortKey="Simmons, Andrew" sort="Simmons, Andrew" uniqKey="Simmons A" first="Andrew" last="Simmons">Andrew Simmons</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157</wicri:regionArea><wicri:noRegion>14157</wicri:noRegion></affiliation></author><author><name sortKey="Westman, Eric" sort="Westman, Eric" uniqKey="Westman E" first="Eric" last="Westman">Eric Westman</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, 14157</wicri:regionArea><wicri:noRegion>14157</wicri:noRegion></affiliation></author></analytic><series><title level="j">Hippocampus</title><idno type="eISSN">1098-1063</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alzheimer's disease is characterized by hippocampal atrophy. Other factors also influence the hippocampal volume, but their interactive effect has not been investigated before in cognitively healthy individuals. The aim of this study is to evaluate the interactive effect of key demographic and clinical factors on hippocampal volume, in contrast to previous studies frequently investigating these factors in a separate manner. Also, to investigate how comparable the control groups from ADNI, AIBL, and AddNeuroMed are with five population-based cohorts. In this study, 1958 participants were included (100 AddNeuroMed, 226 ADNI, 155 AIBL, 59 BRC, 295 GENIC, 279 BioFiNDER, 398 PIVUS, and 446 SNAC-K). ANOVA and random forest were used for testing between-cohort differences in demographic-clinical variables. Multiple regression was used to study the influence of demographic-clinical variables on hippocampal volume. ANCOVA was used to analyze whether between-cohort differences in demographic-clinical variables explained between-cohort differences in hippocampal volume. Age and global brain atrophy were the most important variables in explaining variability in hippocampal volume. These variables were not only important themselves but also in interaction with gender, education, MMSE, and total intracranial volume. AddNeuroMed, ADNI, and AIBL differed from the population-based cohorts in several demographic-clinical variables that had a significant effect on hippocampal volume. Variability in hippocampal volume in individuals with normal cognition is high. Differences that previously tended to be related to disease mechanisms could also be partly explained by demographic and clinical factors independent from the disease. Furthermore, cognitively normal individuals especially from ADNI and AIBL are not representative of the general population. These findings may have important implications for future research and clinical trials, translating imaging biomarkers to the general population, and validating current diagnostic criteria for Alzheimer's disease and predementia stages.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pologne</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>East Middle Sweden</li><li>Oxfordshire</li><li>Svealand</li></region><settlement><li>Oxford</li><li>Stockholm</li><li>Uppsala</li></settlement><orgName><li>Université d'Oxford</li><li>Université d'Uppsala</li></orgName></list><tree><country name="Suède"><noRegion><name sortKey="Ferreira, Daniel" sort="Ferreira, Daniel" uniqKey="Ferreira D" first="Daniel" last="Ferreira">Daniel Ferreira</name></noRegion><name sortKey="Ahlstrom, H Kan" sort="Ahlstrom, H Kan" uniqKey="Ahlstrom H" first="H Kan" last="Ahlström">H Kan Ahlström</name><name sortKey="B Ckman, Lars" sort="B Ckman, Lars" uniqKey="B Ckman L" first="Lars" last="B Ckman">Lars B Ckman</name><name sortKey="Fratiglioni, Laura" sort="Fratiglioni, Laura" uniqKey="Fratiglioni L" first="Laura" last="Fratiglioni">Laura Fratiglioni</name><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><name sortKey="Hansson, Oskar" sort="Hansson, Oskar" uniqKey="Hansson O" first="Oskar" last="Hansson">Oskar Hansson</name><name sortKey="Kalpouzos, Gregoria" sort="Kalpouzos, Gregoria" uniqKey="Kalpouzos G" first="Grégoria" last="Kalpouzos">Grégoria Kalpouzos</name><name sortKey="Larsson, Elna Marie" sort="Larsson, Elna Marie" uniqKey="Larsson E" first="Elna-Marie" last="Larsson">Elna-Marie Larsson</name><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><name sortKey="Lindberg, Olof" sort="Lindberg, Olof" uniqKey="Lindberg O" first="Olof" last="Lindberg">Olof Lindberg</name><name sortKey="Muehlboeck, J Sebastian" sort="Muehlboeck, J Sebastian" uniqKey="Muehlboeck J" first="J-Sebastian" last="Muehlboeck">J-Sebastian Muehlboeck</name><name sortKey="N Gga, Katarina" sort="N Gga, Katarina" uniqKey="N Gga K" first="Katarina" last="N Gga">Katarina N Gga</name><name sortKey="Simmons, Andrew" sort="Simmons, Andrew" uniqKey="Simmons A" first="Andrew" last="Simmons">Andrew Simmons</name><name sortKey="Stomrud, Erik" sort="Stomrud, Erik" uniqKey="Stomrud E" first="Erik" last="Stomrud">Erik Stomrud</name><name sortKey="Wahlund, Lars Olof" sort="Wahlund, Lars Olof" uniqKey="Wahlund L" first="Lars-Olof" last="Wahlund">Lars-Olof Wahlund</name><name sortKey="Westman, Eric" sort="Westman, Eric" uniqKey="Westman E" first="Eric" last="Westman">Eric Westman</name></country><country name="Espagne"><noRegion><name sortKey="Barroso, Jose" sort="Barroso, Jose" uniqKey="Barroso J" first="José" last="Barroso">José Barroso</name></noRegion><name sortKey="Hernandez Cabrera, Juan Andres" sort="Hernandez Cabrera, Juan Andres" uniqKey="Hernandez Cabrera J" first="Juan Andrés" last="Hernández-Cabrera">Juan Andrés Hernández-Cabrera</name><name sortKey="Machado, Alejandra" sort="Machado, Alejandra" uniqKey="Machado A" first="Alejandra" last="Machado">Alejandra Machado</name><name sortKey="Molina, Yaiza" sort="Molina, Yaiza" uniqKey="Molina Y" first="Yaiza" last="Molina">Yaiza Molina</name></country><country name="Australie"><noRegion><name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name></noRegion></country><country name="France"><noRegion><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name></noRegion></country><country name="Grèce"><noRegion><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kłoszewska">Iwona Kłoszewska</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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